反应详情

Compound 46A (210 mg, 0.90 mmol) was dissolved in MeOH (10 mL), K2CO3 was added, and the reaction was stirred at rt for 30 min. The reaction was then concentrated under reduced pressure and subsequently purified by silica gel flash chromatography eluting with 5-10% MeOH/CH2Cl2 (gradient) to give the title compound (162 mg, 94%) as a pink solid. LC/MS m/z 191 [M+H]+.

1. concentrationThe reaction was then concentrated under reduced pressure
2. customsubsequently purified by silica gel flash chromatography
3. washeluting with 5-10% MeOH/CH2Cl2 (gradient)