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HRID751130

反应详情

EQUATION

反应方程式

HRID 751130 的结构方程式

REACTANTS

反应物

2
结构：C[N+]1([O-])CCOCC1
HCID82029

4-Methylmorpholine 4-oxide

C5H11NO2

结构：CC(O)[C@@H]1[C@@H](O[Si](C)(C)C(C)(C)C)CCN1C(=O)OC(C)(C)C
HCID59734597

未命名化合物

PRODUCTS

生成物

1
结构：CC(O)[C@H]1[C@@H](O[Si](C)(C)C(C)(C)C)CCN1C(=O)OC(C)(C)C
HCID66863428

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CCC[N+](CCC)(CCC)CCC.O=[Ru](=O)(=O)[O-]
催化剂HCID178419074

未命名化合物

2 次

结构：CCCCCC
溶剂HCID8058

n-Hexane

C6H14

PROCEDURE

实验过程

To intermediate 61C (0.1 M solution in 10% CH3CN in DCM) add NMO (2 equiv) followed by TPAP (0.05 equiv). Provide sufficient ventilation and take care to watch for exotherm. Stir reaction at rt for 3-5 h. Dilute by half with hexane and allow TPAP to precipitate. Flash filter through silica gel plug (20 fold mass of starting alcohol) and elute with 10% EtOAc/Hex until product is not observed in eluent. Removal of solvents gave the title compound. MS (ES) m/z 344.31 [M+H]+

WORKUP

后处理

  1. customProvide sufficient ventilation
  2. customreaction at rt for 3-5 h
  3. customto precipitate
  4. filtrationFlash filter through silica gel plug (20 fold mass of starting alcohol)
  5. washelute with 10% EtOAc/Hex until product
  6. customRemoval of solvents