4-Amino-2-fluoro-3-methylbenzonitrile → 2-Fluoro-4-isocyanato-3-methylbenzonitrile

HRID 751149Notes

Reaction equation

HRID 751149 reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([F:10])[C:3]=1[CH3:11].N(C1C2CCCCC=2C(C#N)=CC=1)=[C:13]=[O:14]>>[F:10][C:4]1[C:3]([CH3:11])=[C:2]([N:1]=[C:13]=[O:14])[CH:9]=[CH:8][C:5]=1[C:6]#[N:7]

Participants

3

Reactant 2

HCID 450786764-Amino-2-fluoro-3-methylbenzonitrileHCID 597543044-Isocyanato-5,6,7,8-tetrahydronaphthalene-1-carbonitrile

Product 1

HCID 597543172-Fluoro-4-isocyanato-3-methylbenzonitrile

Procedure

2-Fluoro-4-isocyanato-3-methylbenzonitrile was prepared from 4-amino-2-fluoro-3-methyl-benzonitrile (72D) following a procedure analogous to the procedure used in the preparation of compound 2E (Example 2).

Sources & evidence

ORD record
ord-95ef61e937a94324b717bbb350585c08
Source dataset
uspto-grants-2008_07
Patent number
US07405234B2

Reaction notes

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