4-Pentyn-1-ol → 4-Pentyn-1-ol, 5-[3-(trifluoromethoxy)phenyl]-

HRID 751182Notes

Reaction equation

HRID 751182 reaction equation
I[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][C:9]([F:12])([F:11])[F:10])[CH:3]=1.[CH2:13]([OH:18])[CH2:14][CH2:15][C:16]#[CH:17]>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[F:10][C:9]([F:12])([F:11])[O:8][C:4]1[CH:3]=[C:2]([C:17]#[C:16][CH2:15][CH2:14][CH2:13][OH:18])[CH:7]=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 793464-Pentyn-1-olHCID 27772931-Iodo-3-(trifluoromethoxy)benzene

Product 1

HCID 688216934-Pentyn-1-ol, 5-[3-(trifluoromethoxy)phenyl]-

Reagents, catalysts & solvents 1

HCID 178418397HCID 178418397, compoundCatalyst

Procedure

In analogy to the procedure described in example 1 a], 1-iodo-3-trifluoromethoxy-benzene was reacted with 4-pentyn-1-ol in the presence of Pd(PPh3)4 and cuprous iodide to give the title compound as red oil.

Sources & evidence

ORD record
ord-2a7ce73c88bc42b3accbfa0c14609e2e
Source dataset
uspto-grants-2008_07
Patent number
US07405236B2

Reaction notes

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