Lithium Hydroxide → {6-[2,2-Dimethyl-5-(4-trifluoromethoxy-phenyl)-pent-4-ynyloxy]-indol-1-yl}-acetic acid

HRID 751202Notes

Reaction equation

HRID 751202 reaction equation
C([O:3][C:4](=[O:34])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][CH2:16][C:17]([CH3:33])([CH3:32])[CH2:18][C:19]#[C:20][C:21]3[CH:26]=[CH:25][C:24]([O:27][C:28]([F:31])([F:30])[F:29])=[CH:23][CH:22]=3)[CH:13]=2)[CH:8]=[CH:7]1)C.[Li+].[OH-]>>[CH3:32][C:17]([CH3:33])([CH2:18][C:19]#[C:20][C:21]1[CH:22]=[CH:23][C:24]([O:27][C:28]([F:31])([F:29])[F:30])=[CH:25][CH:26]=1)[CH2:16][O:15][C:12]1[CH:13]=[C:14]2[C:9]([CH:8]=[CH:7][N:6]2[CH2:5][C:4]([OH:34])=[O:3])=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 68822721{6-[2,2-Dimethyl-5-(4-trifluoromethoxy-phenyl)-pent-4-ynyloxy]-indol-1-yl}-acetic acid ethyl ester

Product 1

HCID 11604716{6-[2,2-Dimethyl-5-(4-trifluoromethoxy-phenyl)-pent-4-ynyloxy]-indol-1-yl}-acetic acid

Procedure

In analogy to the procedure described for example 1 e], {6-[2,2-dimethyl-5-(4-trifluoromethoxy-phenyl)-pent-4-ynyloxy]-indol-1-yl}-acetic acid ethyl ester was treated with LiOH to obtain the title compound as brown oil.

Sources & evidence

ORD record
ord-51965b680b664249b2afcaa8d15254c2
Source dataset
uspto-grants-2008_07
Patent number
US07405236B2

Reaction notes

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