HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl bromoacetate → [7-(tert-Butyl-dimethyl-silanyloxy)-indol-1-yl]-acetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 7-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-1H-indole | HCID 57110974 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | [7-(tert-Butyl-dimethyl-silanyloxy)-indol-1-yl]-acetic acid ethyl ester | HCID 68824002 | — |
Reaction Steps
In analogy to the procedure described in example 6 b], 7-(tert-butyl-dimethyl-silanyloxy)-1H-indole (EP 206225 A2) was reacted with ethyl bromoacetate in the presence of cesium carbonate in acetonitrile to give the title compound as colorless liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07405236B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-e6325e077dd348f6ae14e2fa726508fb |
| Source note | uspto-grants-2008_07 |