1-Butanaminium, N,N,N-tributyl-, fluoride, hydrate → (7-Hydroxy-indol-1-yl)-acetic acid ethyl ester

HRID 751215Notes

Reaction equation

HRID 751215 reaction equation
[CH2:1]([O:3][C:4](=[O:23])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][C:13]=2[O:15][Si](C(C)(C)C)(C)C)[CH:8]=[CH:7]1)[CH3:2].O.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>>[CH2:1]([O:3][C:4](=[O:23])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][C:13]=2[OH:15])[CH:8]=[CH:7]1)[CH3:2]

Participants

3

Reactant 2

HCID 162116731-Butanaminium, N,N,N-tributyl-, fluoride, hydrateHCID 68824002[7-(tert-Butyl-dimethyl-silanyloxy)-indol-1-yl]-acetic acid ethyl ester

Product 1

HCID 68821713(7-Hydroxy-indol-1-yl)-acetic acid ethyl ester

Procedure

In analogy to the procedure described in example 6 c], [7-(tert-butyl-dimethyl-silanyloxy)-indol-1-yl]-acetic acid ethyl ester was treated with tetrabutylammonium fluoride hydrate to give the title compound as colorless solid.

Sources & evidence

ORD record
ord-3367a52c6b8f43d4985446b56cff5a77
Source dataset
uspto-grants-2008_07
Patent number
US07405236B2

Reaction notes

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