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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 751219Generated: October 25, 2026

Lithium Hydroxide → [Rac]-2-{6-[5-(4-trifluoromethoxy-phenyl)-pent-4-ynyloxy]-indol-1-yl}-propionic acid

https://huagongshe.com/reaction/751219

Reaction equation

Participants

RoleNameHCIDCharge
ReactantLithium HydroxideHCID 3939—
Reactant[rac]-2-{6-[5-(4-Trifluoromethoxy-phenyl)-pent-4-ynyloxy]-indol-1-yl]-propionic acid ethyl esterHCID 68824015—
Product[Rac]-2-{6-[5-(4-trifluoromethoxy-phenyl)-pent-4-ynyloxy]-indol-1-yl}-propionic acidHCID 11626159—

Reaction Steps

In analogy to the procedure described for example 1 e], [rac]-2-{6-[5-(4-trifluoromethoxy-phenyl)-pent-4-ynyloxy]-indol-1-yl}-propionic acid ethyl ester was treated with LiOH to obtain the title compound as yellow oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07405236B2
Source datasetuspto-grants-2008_07
ORD IDord-f0973ee4f53146039cda8db7df5044bb
Source noteuspto-grants-2008_07