Lithium Hydroxide → [Rac]-2-{6-[5-(4-trifluoromethoxy-phenyl)-pent-4-ynyloxy]-indol-1-yl}-propionic acid

HRID 751219Notes

Reaction equation

HRID 751219 reaction equation
C([O:3][C:4](=[O:33])[CH:5]([N:7]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:16][CH2:17][CH2:18][CH2:19][C:20]#[C:21][C:22]3[CH:27]=[CH:26][C:25]([O:28][C:29]([F:32])([F:31])[F:30])=[CH:24][CH:23]=3)[CH:14]=2)[CH:9]=[CH:8]1)[CH3:6])C.[Li+].[OH-]>>[F:31][C:29]([F:30])([F:32])[O:28][C:25]1[CH:24]=[CH:23][C:22]([C:21]#[C:20][CH2:19][CH2:18][CH2:17][O:16][C:13]2[CH:14]=[C:15]3[C:10]([CH:9]=[CH:8][N:7]3[CH:5]([CH3:6])[C:4]([OH:33])=[O:3])=[CH:11][CH:12]=2)=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 68824015[rac]-2-{6-[5-(4-Trifluoromethoxy-phenyl)-pent-4-ynyloxy]-indol-1-yl]-propionic acid ethyl ester

Product 1

HCID 11626159[Rac]-2-{6-[5-(4-trifluoromethoxy-phenyl)-pent-4-ynyloxy]-indol-1-yl}-propionic acid

Procedure

In analogy to the procedure described for example 1 e], [rac]-2-{6-[5-(4-trifluoromethoxy-phenyl)-pent-4-ynyloxy]-indol-1-yl}-propionic acid ethyl ester was treated with LiOH to obtain the title compound as yellow oil.

Sources & evidence

ORD record
ord-f0973ee4f53146039cda8db7df5044bb
Source dataset
uspto-grants-2008_07
Patent number
US07405236B2

Reaction notes

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