Benzene, 1-iodo-4-(trifluoromethyl)- → HCID 68822788, compound

HRID 751226Notes

Reaction equation

HRID 751226 reaction equation
[CH2:1]([O:8][C:9](=[O:14])[CH2:10][CH2:11][C:12]#[CH:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.I[C:16]1[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=1>>[CH2:1]([O:8][C:9](=[O:14])[CH2:10][CH2:11][C:12]#[C:13][C:16]1[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 67993Benzene, 1-iodo-4-(trifluoromethyl)-HCID 561097Benzyl 4-pentynoate

Product 1

HCID 68822788HCID 68822788, compound

Procedure

In analogy to the procedure described for example 8 a], pent-4-ynoic acid benzyl ester (Rosowsky, Andre; Forsch, Ronald A.; Queener, Sherry F., Journal of Medicinal Chemistry (2003), 46(9), 1726-1736) was reacted with 4-iodobenzotrifluoride in the presence of PdCl2(Ph3P)2 and cuprous iodide to give the title compound as yellow oil.

Sources & evidence

ORD record
ord-625768926b0d45b2adacf1eb69887c05
Source dataset
uspto-grants-2008_07
Patent number
US07405236B2

Reaction notes

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