HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene, 1-iodo-4-(trifluoromethyl)- → HCID 68822788, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene, 1-iodo-4-(trifluoromethyl)- | HCID 67993 | — |
| Reactant | Benzyl pent-4-ynoate | HCID 561097 | — |
| Product | HCID 68822788 | HCID 68822788 | — |
Reaction Steps
In analogy to the procedure described for example 8 a], pent-4-ynoic acid benzyl ester (Rosowsky, Andre; Forsch, Ronald A.; Queener, Sherry F., Journal of Medicinal Chemistry (2003), 46(9), 1726-1736) was reacted with 4-iodobenzotrifluoride in the presence of PdCl2(Ph3P)2 and cuprous iodide to give the title compound as yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07405236B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-625768926b0d45b2adacf1eb69887c05 |
| Source note | uspto-grants-2008_07 |