Lithium Hydroxide → HCID 68824010, compound

HRID 751227Notes

Reaction equation

HRID 751227 reaction equation
C([O:8][C:9](=[O:24])[CH2:10][CH2:11][C:12]#[C:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=1)C1C=CC=CC=1.[Li+].[OH-]>>[F:21][C:20]([F:22])([F:23])[C:17]1[CH:16]=[CH:15][C:14]([C:13]#[C:12][CH2:11][CH2:10][C:9]([OH:24])=[O:8])=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 68822788HCID 68822788, compound

Product 1

HCID 68824010HCID 68824010, compound

Procedure

In analogy to the procedure described for example 1 e], 5-(4-trifluoromethyl-phenyl)-pent-4-ynoic acid benzyl ester was treated with LiOH to obtain the title compound as off-white solid.

Sources & evidence

ORD record
ord-61fbc38e5ffe4b03ad9a6047fc73238d
Source dataset
uspto-grants-2008_07
Patent number
US07405236B2

Reaction notes

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