Lithium Hydroxide → HCID 11561035, compound

HRID 751240Notes

Reaction equation

C([O:3][C:4](=[O:33])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][CH:16]([CH3:32])[CH2:17][CH2:18][C:19]#[C:20][C:21]3[CH:26]=[CH:25][C:24]([O:27][C:28]([F:31])([F:30])[F:29])=[CH:23][CH:22]=3)[CH:13]=2)[CH:8]=[CH:7]1)C.[Li+].[OH-]>>[CH3:32][CH:16]([O:15][C:12]1[CH:13]=[C:14]2[C:9]([CH:8]=[CH:7][N:6]2[CH2:5][C:4]([OH:33])=[O:3])=[CH:10][CH:11]=1)[CH2:17][CH2:18][C:19]#[C:20][C:21]1[CH:26]=[CH:25][C:24]([O:27][C:28]([F:31])([F:30])[F:29])=[CH:23][CH:22]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 68821733HCID 68821733, compound

Product 1

HCID 11561035HCID 11561035, compound

Procedure

In analogy to the procedure described for example 1 e], [rac]-{6-[1-methyl-5-(4-trifluoromethoxy-phenyl)-pent-4-ynyloxy]-indol-1-yl}-acetic acid ethyl ester was treated with LiOH to obtain the title compound as brown crystals.

Sources & evidence

ORD record: ord-355e3be7a4774172b218790ff15e238b
Source dataset: uspto-grants-2008_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07405236B2

Reaction notes

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