Sodium Hydroxide → HCID 178492419, compound

HRID 751247Notes

Reaction equation

HRID 751247 reaction equation
C[O:2][C:3](=[O:13])[C@H:4]([CH2:6][CH2:7][CH2:8][NH:9][C:10](=[NH:12])[NH2:11])[NH2:5].[CH3:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([N:22]=[N:23][C:24]([NH:26][C@H:27]([C:35](O)=[O:36])[CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[O:25])=[CH:18][CH:17]=1.[OH-].[Na+]>O.CO>[CH3:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([N:22]=[N:23][C:24]([NH:26][C@H:27]([C:35]([NH:5][C@H:4]([C:3]([OH:2])=[O:13])[CH2:6][CH2:7][CH2:8][NH:9][C:10](=[NH:12])[NH2:11])=[O:36])[CH2:28][C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)=[O:25])=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178501502HCID 178501502, compound

Product 1

HCID 178492419HCID 178492419, compound

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

Operating mode: 1 equivalent of N-(4-methoxyphenylazoformyl)L-phenylalanine arginine methyl ester was taken up in a water/methanol mixture (ratio: 1/2; 3 ml/mmol). 3 equivalent of 1 N sodium hydroxide was added. After 1 h, the reactional medium was acidified, concentrated then extracted with water/dichloromethane. The dichioromethane phase was evaporated then dried. N-(4-methoxyphenylazoformyl)-L-phenylalanyl arginine was obtained as an orange powder.

Workup

  1. concentrationconcentrated
  2. extractionthen extracted with water/dichloromethane
  3. customThe dichioromethane phase was evaporated
  4. customthen dried

Sources & evidence

ORD record
ord-e17b668793fc448c91a392414d4c53e0
Source dataset
uspto-grants-2008_07
Patent number
US07405280B2

Reaction notes

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