HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → (5-Iodopyridin-2-yl)-methylene-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | 2-Pyridinamine, 5-iodo- | HCID 88579 | — |
| Catalyst | Trifluoroacetic acid | HCID 6422 | — |
| Product | (5-Iodopyridin-2-yl)-methylene-amine | HCID 58611975 | 76.6% |
Reaction Steps
Add trifluoroacetic acid (3 drops) to a suspension of 2-amino-5-iodopyridine (1.0 g, 4.5 mmol) and paraformaldehyde (1.0 g). Heat the mixture at reflux for 15 h and concentrate. Purification by flash chromatography eluting with ethyl acetate gives 0.8 g (75%) of the title compound as a white solid. ES+ m/e 232.6 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07405299B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-c30ff42efef54040ada30ab2e70ed825 |
| Source note | uspto-grants-2008_07 |