反应详情

Add trifluoroacetic acid (3 drops) to a suspension of 2-amino-5-iodopyridine (1.0 g, 4.5 mmol) and paraformaldehyde (1.0 g). Heat the mixture at reflux for 15 h and concentrate. Purification by flash chromatography eluting with ethyl acetate gives 0.8 g (75%) of the title compound as a white solid. ES+ m/e 232.6 (M+1).

1. temperatureHeat the mixture
2. temperatureat reflux for 15 h
3. concentrationconcentrate
4. customPurification by flash chromatography
5. washeluting with ethyl acetate