HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl 4-bromo-1H-indole-1-carboxylate → 4-[2-(Pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]-indole-1-carboxylic Acid tert-Butyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl 4-bromo-1H-indole-1-carboxylate | HCID 40425427 | — |
| Reactant | (2-pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-3-boronic acid | HCID 59710031 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-[2-(Pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]-indole-1-carboxylic Acid tert-Butyl Ester | HCID 58611961 | — |
Reaction Steps
The titled intermediate was made via Preparation 33 (General Suzuki Coupling Method D) from 4-bromo-indole-1-carboxylic acid tert-butyl ester and 2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-3-boronic acid (Preparation 5). MS (ESI) m/e 401 (M+1). TLC (SiO2): Rf0.5 (1:1 methylene chloride/[80:18:2 chloroform/methanol/concentrated aqueous ammonium hydroxide]).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07405299B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-f560e80ea8f94713961b306c55110111 |
| Source note | uspto-grants-2008_07 |