Piperazine → HCID 59754754, compound

HRID 751336Notes

Reaction equation

HRID 751336 reaction equation
Cl[C:2]1[N:3]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:4]2[C:9]([C:10]=1[CH:11]=[O:12])=[CH:8][C:7]([CH3:13])=[CH:6][CH:5]=2.[NH:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[CH3:13][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:2]([N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1)=[C:10]2[CH:11]=[O:12]

Participants

3

Reactant 2

HCID 4837PiperazineHCID 86035890HCID 86035890, compound

Product 1

HCID 59754754HCID 59754754, compoundYield 63%

Procedure

2-Chloro-5-methyl-1-phenyl-1H-indole-3-carboxaldehyde is reacted with piperazine as described in Example 2 to give 5-methyl-1-phenyl-2-(piperazin-1-yl)-1H-indole-3-carboxaldehyde as a pale yellow solid (63% yield).

Sources & evidence

ORD record
ord-095828be518b4bf681f2efdce0861861
Source dataset
uspto-grants-2008_07
Patent number
US07405300B2

Reaction notes

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