Piperazine → HCID 11381599, compound

HRID 751341Notes

Reaction equation

HRID 751341 reaction equation
Cl[C:2]1[N:3]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:4]2[C:9]([C:10]=1[CH:11]=[O:12])=[CH:8][CH:7]=[CH:6][CH:5]=2.[NH:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[N:20]1([C:2]2[N:3]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:4]3[C:9]([C:10]=2[CH:11]=[O:12])=[CH:8][CH:7]=[CH:6][CH:5]=3)[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 4837PiperazineHCID 105639332-Chloro-1-benzyl-1H-indole-3-carboxaldehyde

Product 1

HCID 11381599HCID 11381599, compoundYield 64%

Procedure

2-Chloro-1-benzyl-1H-indole-3-carboxaldehyde (1.0 g, 5.5 mmol) is reacted with piperazine as described in Example 2 to yield the title compound (64%), mp 163-165° C., as a pale yellow solid. MS 320 (M+H).

Sources & evidence

ORD record
ord-16f0f794b3c74d598e27b9d3691be47d
Source dataset
uspto-grants-2008_07
Patent number
US07405300B2

Reaction notes

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