Piperazine → HCID 11461092, compound

HRID 751345Notes

Reaction equation

HRID 751345 reaction equation
Cl[C:2]1[N:3]([C:13]2[CH:17]=[CH:16][S:15][CH:14]=2)[C:4]2[C:9]([C:10]=1[CH:11]=[O:12])=[CH:8][CH:7]=[CH:6][CH:5]=2.[NH:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1>>[N:18]1([C:2]2[N:3]([C:13]3[CH:17]=[CH:16][S:15][CH:14]=3)[C:4]3[C:9]([C:10]=2[CH:11]=[O:12])=[CH:8][CH:7]=[CH:6][CH:5]=3)[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 4837PiperazineHCID 86035948HCID 86035948, compound

Product 1

HCID 11461092HCID 11461092, compoundYield 78%

Procedure

2-Chloro-1-(thien-3-yl)-1H-indole-3-carboxaldehyde as prepared above is reacted with piperazine as described in Example 3 to give the title compound as a pale yellow solid (78% yield). MS 409 (M+H)

Sources & evidence

ORD record
ord-2abc309d12c54045885965ad5918a498
Source dataset
uspto-grants-2008_07
Patent number
US07405300B2

Reaction notes

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