Piperazine → HCID 25052276, compound

HRID 751353Notes

Reaction equation

HRID 751353 reaction equation
Cl[CH:2]1[N:10]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[CH:3]1[CH:17]=[O:18].[NH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[C:11]1([N:10]2[C:5]3=[N:6][CH:7]=[CH:8][CH:9]=[C:4]3[CH:3]([CH:17]=[O:18])[CH:2]2[N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 4837PiperazineHCID 86596809HCID 86596809, compound

Product 1

HCID 25052276HCID 25052276, compoundYield 63%

Procedure

2-Chloro-1-phenyl-1,3-dihydropyrrolo[2,3-b]pyridine-3-carboxaldehyde is reacted with piperazine as described in Example 2 to give 1-phenyl-2-(piperazin-1-yl)-1,3-dihydropyrrolo[2,3-b]pyridine-3-carboxaldehyde (63% yield).

Sources & evidence

ORD record
ord-53566f994e6540498530d41e1fe2a0fc
Source dataset
uspto-grants-2008_07
Patent number
US07405300B2

Reaction notes

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