HCID 67371284, compound → HCID 67371597, compound

HRID 751357Notes

Reaction equation

HRID 751357 reaction equation
[CH2:1]([O:8][C:9](=[O:20])[CH2:10][C:11]1[CH:16]=[CH:15][N:14]=[CH:13][C:12]=1[N+:17]([O-])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Pd]>[CH2:1]([O:8][C:9](=[O:20])[CH2:10][C:11]1[CH:16]=[CH:15][N:14]=[CH:13][C:12]=1[NH2:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 67371284HCID 67371284, compound

Product 1

HCID 67371597HCID 67371597, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The title compound is prepared following the procedures of WO, 00 55159 as follows. A mixture of (3-nitropyridin-4-yl)acetic acid benzyl ester (1.10 g, 5.23 mmol), 10% palladium on charcoal (200 mg) and denatured alcohol (100 mL) is stirred under an atmosphere of hydrogen for 6 hr. The catalyst is removed by filtration through a pad of Hi-Flo and the filtrate is concentrated to yield (3-aminopyridin-4-yl)acetic acid benzyl ester (0.92 g, 98% yield) as a yellow-brown oil. MS 181 (M+H).

Workup

  1. customThe title compound is prepared
  2. customThe catalyst is removed by filtration through a pad of Hi-Flo
  3. concentrationthe filtrate is concentrated

Sources & evidence

ORD record
ord-7be25a26396c4060ab52689b0ddfeece
Source dataset
uspto-grants-2008_07
Patent number
US07405300B2

Reaction notes

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