Piperazine → HCID 11209800, compound

HRID 751387Notes

Reaction equation

Cl[C:2]1[N:3]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([CH:19]=[O:20])[CH:14]=2)[C:4]2[C:9]([C:10]=1[CH:11]=[O:12])=[CH:8][CH:7]=[CH:6][CH:5]=2.[NH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[CH:19]([C:15]1[CH:14]=[C:13]([N:3]2[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[C:10]([CH:11]=[O:12])=[C:2]2[CH:22]2[CH2:23][NH:24][CH2:25][CH2:26][NH:21]2)[CH:18]=[CH:17][CH:16]=1)=[O:20]

Participants

Reactant 2

HCID 4837Piperazine

HCID 86035888HCID 86035888, compound

Product 1

HCID 11209800HCID 11209800, compoundYield 59%

Procedure

2-Chloro-1-(3-formylphenyl)-1H-indole-3-carboxaldehyde is reacted with piperazine as described in Step 2 of Example 29 to afford 1-(3-formylphenyl)-2-(piperazin-2-yl)-1H-indole-3-carboxaldehyde (59% yield) as a cream solid. ESI/MS 334 (M+H); RT 2.29 min.

Sources & evidence

ORD record: ord-ac47b703d5da421d908be04a4a158a05
Source dataset: uspto-grants-2008_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07405300B2

Reaction notes

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