Piperazine → HCID 11450645, compound

HRID 751404Notes

Reaction equation

HRID 751404 reaction equation
Cl[C:2]1[N:3]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([Cl:19])[CH:14]=2)[C:4]2[C:9]([C:10]=1[CH:11]=[O:12])=[CH:8][CH:7]=[CH:6][CH:5]=2.[NH:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[Cl:19][C:15]1[CH:14]=[C:13]([N:3]2[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[C:10]([CH:11]=[O:12])=[C:2]2[N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[CH:18]=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 4837PiperazineHCID 86035936HCID 86035936, compound

Product 1

HCID 11450645HCID 11450645, compoundYield 64%

Procedure

2-Chloro-1-(3-chlorophenyl)-1H-indole-3-carboxaldehyde is reacted with piperazine as described in Step 2 of Example 29 to afford 1-(3-chlorophenyl-2-(piperazin-1-yl)-1H-indole-3-carboxaldehyde (64% yield) as a cream solid. ESI/MS 340 (M+H); RT 2.66 min.

Sources & evidence

ORD record
ord-eb4cf98a9e674f8d99f8a8646c22c22c
Source dataset
uspto-grants-2008_07
Patent number
US07405300B2

Reaction notes

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