Piperazine → HCID 11198298, compound

HRID 751417Notes

Reaction equation

HRID 751417 reaction equation
Cl[C:2]1[N:3]([C:13]2[CH:20]=[CH:19][C:16]([C:17]#[N:18])=[CH:15][CH:14]=2)[C:4]2[C:9]([C:10]=1[CH:11]=[O:12])=[CH:8][CH:7]=[CH:6][CH:5]=2.[NH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[CH:11]([C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]([C:13]2[CH:20]=[CH:19][C:16]([C:17]#[N:18])=[CH:15][CH:14]=2)[C:2]=1[N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1)=[O:12]

Participants

3

Reactant 2

HCID 4837PiperazineHCID 86035952HCID 86035952, compound

Product 1

HCID 11198298HCID 11198298, compound

Procedure

4-(2-chloro-3-formylindol-1-yl)-benzonitrile is reacted with piperazine as described in Step 2 of Example 29 to afford 4-[3-formyl-2-(piperazin-1-yl)-indol-1-yl]-benzonitrile as a light tan solid. ESI/MS 331 (M+H); NMR (CDCl3) 10.35 (1H, s); 8.31 (1H, d, J=9 Hz); 7.92 (2H, d); 7.60 (2H, d); 7.31 (3H, m); 6.99 (1H, d, J=9 Hz); 3.28 (4H, m); 2.79 (4H, m).

Sources & evidence

ORD record
ord-e822126e4e23452ea3d78beb671a2baa
Source dataset
uspto-grants-2008_07
Patent number
US07405300B2

Reaction notes

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