Hydrochloric Acid → HCID 53929954, compound

HRID 751455Notes

Reaction equation

HRID 751455 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[CH2:17][CH2:16][CH2:15][CH:14]([NH:18][C:19](=[O:33])[C@@H:20]([NH:25]C(OC(C)(C)C)=O)[CH2:21][CH:22]([CH3:24])[CH3:23])[CH:13]([OH:34])[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>CO.O1CCOCC1>[CH2:1]([O:8][C:9]([N:11]1[CH2:17][CH2:16][CH2:15][CH:14]([NH:18][C:19](=[O:33])[C@@H:20]([NH2:25])[CH2:21][CH:22]([CH3:24])[CH3:23])[CH:13]([OH:34])[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 54120137HCID 54120137, compound

Product 1

HCID 53929954HCID 53929954, compoundYield 120.2%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of 4-((S)-2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-3-hydroxy-azepan-1-carboxylic acid benzyl ester of Example 2f (4.0 g) in methanol (20 mL) was added 4M HCl in dioxane (20 mL). The reaction was stirred at room temperature for 2 hours whereupon it was concentrated to provide the title compound (3.8 g): MS(EI) 378 (M+H+).

Workup

  1. concentrationwas concentrated

Sources & evidence

ORD record
ord-c88f47d5454747f8a1b6abac981bd6ff
Source dataset
uspto-grants-2008_07
Patent number
US07405209B2

Reaction notes

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