HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethane, 2-bromo-1,1-diethoxy- → 5-Bromoimidazo[1,2-a]pyridine hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethane, 2-bromo-1,1-diethoxy- | HCID 74852 | — |
| Reactant | 2-Amino-6-bromopyridine | HCID 300809 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 5-Bromoimidazo[1,2-a]pyridine hydrobromide | HCID 17985430 | 81.1% |
Reaction Steps
Add 2-bromo-1,1-diethoxyethane (3.64 g, 18.48 mmol) to a solution of 6-bromopyridin-2-ylamine (1.0 g, 5.77 mmol) in n-butanol (40 ml). Reflux overnight and cool. Filtration of the reaction mixture gives 1.3 g (81%) of 5-bromoimidazo[1,2-a]pyridine hydrobromide as a white solid. ESMS (M++1): 198.9 m/z.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07405305B2 |
| Source dataset | uspto-grants-2008_07 |
| ORD ID | ord-60d5351cef8649228400a2c480c3f9e2 |
| Source note | uspto-grants-2008_07 |