反应详情

Add 2-bromo-1,1-diethoxyethane (3.64 g, 18.48 mmol) to a solution of 6-bromopyridin-2-ylamine (1.0 g, 5.77 mmol) in n-butanol (40 ml). Reflux overnight and cool. Filtration of the reaction mixture gives 1.3 g (81%) of 5-bromoimidazo[1,2-a]pyridine hydrobromide as a white solid. ESMS (M++1): 198.9 m/z.

1. temperatureReflux overnight
2. temperaturecool
3. filtrationFiltration of the reaction mixture