反应详情

温度

65 °C

To a solution of (S)-2-((1-adamantylmethyl)amino)-1-phenylethanol (50 mg, 0.18 mmol) in dry CH3OH (5 mL) was added PtO2 (10 mg) as the catalyst. The mixture was stirred under hydrogen (55 psi) at 60-70° C. overnight. After filtration, the filtrate was evaporated to give a residue, which was purified by preparative TLC to give (S)-1-cyclohexyl-2-((1-adamantylmethyl)amino)ethanol (20 mg, 40%). 1H NMR (MeOD, 400 MHZ): δ=1.07-1.99 (m, 25H), 2.35-2.51 (q, 2H), 2.63 (t, 1H), 2.80 (d, 1H), 3.51 (m, 1H).

1. filtrationAfter filtration
2. customthe filtrate was evaporated
3. customto give a residue, which
4. customwas purified by preparative TLC