Ammonia → Imidazo(1,2-a)pyridine-3-acetamide
Reaction equation
[NH3:1].C([O:4][C:5](=O)[CH2:6][C:7]1[N:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]2=[N:9][CH:8]=1)C>CO>[N:9]1[CH:8]=[C:7]([CH2:6][C:5]([NH2:1])=[O:4])[N:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=12Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 100 °C
Procedure
Bubble ammonia through a solution of (Imidazo[1,2-a]pyridin-3-yl)acetic acid ethyl ester (10.0 g, 48.96 mmol) in methanol (30 ml) at 0° C. Heat the reaction mixture in a sealed tube at 100° C. for 2 hours. Concentrate the reaction mixture under reduced pressure. Tituration in ethyl acetate to gives the title compound (5.0 g, 58.2%), as a white solid. ESMS (M++1): 176.1 m/z.
Workup
- concentrationConcentrate the reaction mixture under reduced pressure
Sources & evidence
- ORD record
- ord-92dba0a070c64ac5b75d8433fd7153a3
- Source dataset
- uspto-grants-2008_07
- Patent number
- US07405305B2
Reaction notes
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