Ammonia → Imidazo(1,2-a)pyridine-3-acetamide

Participants

Reaction Conditions

Reaction Steps

Bubble ammonia through a solution of (Imidazo[1,2-a]pyridin-3-yl)acetic acid ethyl ester (10.0 g, 48.96 mmol) in methanol (30 ml) at 0° C. Heat the reaction mixture in a sealed tube at 100° C. for 2 hours. Concentrate the reaction mixture under reduced pressure. Tituration in ethyl acetate to gives the title compound (5.0 g, 58.2%), as a white solid. ESMS (M++1): 176.1 m/z.

Provenance & Evidence