Hydrochloric Acid → HCID 69267676, compound

Participants

Reaction Steps

Dissolve 3-(Benzofur-7-yl)-4-[1-(1,4-dioxa-spiro[4.5]dec-8-yl)-4-fluoro-1H-indol-3-yl]pyrrole-2,5-dione (1.40 g, 2.88 mmol) in tetrahydrofuran (20 mL) and stir at room temperature. Add 1N hydrochloric acid (20 mL) and heat the reaction to reflux for 24 h. Upon completion, Filter the product, rinse with cold water, and dry under vaccuum. The orange solid is used without further purification, 1.1 g (87%). MS (ES, m/z): 443.18(M++1), 441.13(M+−1).

Provenance & Evidence