Hydrochloric Acid → HCID 69267676, compound

HRID 751540Notes

Reaction equation

HRID 751540 reaction equation
[O:1]1[C:5]2[C:6]([C:10]3[C:11](=[O:36])[NH:12][C:13](=[O:35])[C:14]=3[C:15]3[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][C:22]=4F)[N:17]([CH:25]4[CH2:34][CH2:33][C:28]5(OCC[O:29]5)[CH2:27][CH2:26]4)[CH:16]=3)=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[CH:2]1.Cl>O1CCCC1>[O:1]1[C:5]2[C:6]([C:10]3[C:11](=[O:36])[NH:12][C:13](=[O:35])[C:14]=3[C:15]3[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[N:17]([CH:25]4[CH2:34][CH2:33][C:28](=[O:29])[CH2:27][CH2:26]4)[CH:16]=3)=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[CH:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69267738HCID 69267738, compound

Product 1

HCID 69267676HCID 69267676, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Dissolve 3-(Benzofur-7-yl)-4-[1-(1,4-dioxa-spiro[4.5]dec-8-yl)-4-fluoro-1H-indol-3-yl]pyrrole-2,5-dione (1.40 g, 2.88 mmol) in tetrahydrofuran (20 mL) and stir at room temperature. Add 1N hydrochloric acid (20 mL) and heat the reaction to reflux for 24 h. Upon completion, Filter the product, rinse with cold water, and dry under vaccuum. The orange solid is used without further purification, 1.1 g (87%). MS (ES, m/z): 443.18(M++1), 441.13(M+−1).

Workup

  1. temperatureheat
  2. customthe reaction
  3. temperatureto reflux for 24 h
  4. filtrationUpon completion, Filter the product
  5. washrinse with cold water
  6. customdry under vaccuum
  7. customThe orange solid is used without further purification, 1.1 g (87%)

Sources & evidence

ORD record
ord-6fa3d86853054960ba477965743f444c
Source dataset
uspto-grants-2008_07
Patent number
US07405305B2

Reaction notes

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