Hydrochloric Acid → 4-Methoxypiperidine hydrochloride

HRID 751643Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 751643
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([O:14][CH3:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:16]>CO.O1CCOCC1.O>[ClH:16].[CH3:15][O:14][CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Komponenten

6

Edukt 2

HCID 313Hydrochloric AcidHCID 21955381Tert-butyl 4-methoxypiperidine-1-carboxylate

Produkt 1

HCID 115428134-Methoxypiperidine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

To a solution of 4-methoxypiperidine-1-carboxylic acid tert-butyl ester (Preparation 67, 1.58 g, 7.34 mmol) in methanol (20 mL) was added hydrochloric acid in 1,4-dioxane (4M, 10 mL) and the mixture stirred for 3 h at rt. Concentration in vacuo gave an oil which was redissolved in water (100 mL). The aqueous layer was washed with ethyl acetate (2×30 mL) and concentrated to give the title compound as colourless solid. δH (D2O): 1.80, 2.14 (4H, 2m), 3.13 (2H, m), 3.38 (2H, m), 3.40 (3H, s), 3.68 (m, 1H).

Aufarbeitung

  1. concentrationConcentration in vacuo
  2. customgave an oil which
  3. washThe aqueous layer was washed with ethyl acetate (2×30 mL)
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-695a160365524c4b9893687a86ab4ede
Quelldatensatz
uspto-grants-2008_07
Patentnummer
US07405210B2

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