p-Fluorophenethylamine → HCID 11267105, compound

HRID 751684Notes

Reaction equation

HRID 751684 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[CH:10]=[C:9]([C:11]([OH:13])=O)[NH:8][C:5]2=[CH:6][N:7]=1.[F:14][C:15]1[CH:23]=[CH:22][C:18]([CH2:19][CH2:20][NH2:21])=[CH:17][CH:16]=1>>[F:14][C:15]1[CH:23]=[CH:22][C:18]([CH2:19][CH2:20][NH:21][C:11]([C:9]2[NH:8][C:5]3=[CH:6][N:7]=[C:2]([Cl:1])[CH:3]=[C:4]3[CH:10]=2)=[O:13])=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 4653p-FluorophenethylamineHCID 446307045-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid

Product 1

HCID 11267105HCID 11267105, compound

Procedure

The title compound was prepared as outlined in EXAMPLE 1 from 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid (Preparation 18) and 4-fluorophenethylamine. The product was purified by mass directed purification to give the title compound as an orange solid. δH (CD3OD): 2.93 (2H, t), 3.60 (2H, t), 6.97–7.04 (3H, m), 7.24–7.30 (2H, m), 7.65 (1H, s), 8.56 (1H, s); m/z (ES+)=318 [M+H]+.

Workup

  1. customThe title compound was prepared
  2. customThe product was purified by mass
  3. custompurification

Sources & evidence

ORD record
ord-5083e88e2ae14db1a6bb9c2ef9aea485
Source dataset
uspto-grants-2008_07
Patent number
US07405210B2

Reaction notes

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