2-Aminomethyl-1,4-benzodioxane → HCID 11484695, compound

HRID 751686Notes

Reaction equation

HRID 751686 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[CH:10]=[C:9]([C:11]([OH:13])=O)[NH:8][C:5]2=[CH:6][N:7]=1.[O:14]1[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=2[O:17][CH2:16][CH:15]1[CH2:24][NH2:25]>>[O:14]1[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=2[O:17][CH2:16][CH:15]1[CH2:24][NH:25][C:11]([C:9]1[NH:8][C:5]2=[CH:6][N:7]=[C:2]([Cl:1])[CH:3]=[C:4]2[CH:10]=1)=[O:13]

Participants

3

Reactant 2

HCID 150532-Aminomethyl-1,4-benzodioxaneHCID 446307045-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid

Product 1

HCID 11484695HCID 11484695, compound

Procedure

The title compound was prepared as outlined in EXAMPLE 1 from 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid (Preparation 18) and 2,3-dihydrobenzo[1,4]dioxin-2-ylmethylamine. The product was purified by mass directed purification to give the title compound as a yellow solid. δH (CD3OD): 3.69–3.73 (2H, m), 3.97–4.03 (1H, m), 4.32–4.42 (2H, m), 6.77–6.88 (4H, m), 7.10 (1H, s), 7.67 (1H, s), 8.58 (1H, s); m/z (ES+)=344 [M+H]+.

Workup

  1. customThe title compound was prepared
  2. customThe product was purified by mass
  3. custompurification

Sources & evidence

ORD record
ord-64b5dd7eaa8749d89dbfeeaf64b828e7
Source dataset
uspto-grants-2008_07
Patent number
US07405210B2

Reaction notes

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