Piperidin-4-ol → HCID 59753585, compound

HRID 751722Notes

Reaction equation

HRID 751722 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[CH:10]=[C:9]([C:11]([NH:13][C@@H:14]([CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:15]([OH:17])=O)=[O:12])[NH:8][C:5]2=[CH:6][N:7]=1.[OH:25][CH:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>>[CH2:18]([C@H:14]([NH:13][C:11]([C:9]1[NH:8][C:5]2=[CH:6][N:7]=[C:2]([Cl:1])[CH:3]=[C:4]2[CH:10]=1)=[O:12])[C:15]([N:29]1[CH2:30][CH2:31][CH:26]([OH:25])[CH2:27][CH2:28]1)=[O:17])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 79341Piperidin-4-olHCID 11382331HCID 11382331, compound

Product 1

HCID 59753585HCID 59753585, compound

Procedure

The title compound was prepared according to EXAMPLE 229 using 2-(S)-[(5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carbonyl)amino]-3-phenylpropionic acid (EXAMPLE 42) and 4-hydroxypiperidine. Purification by chromatography using dichloromethane/methanol (9:1) as the eluent gave the title compound as an orange powder. m/z (ES+)=427.35 [M+H]+; RT=2.99 min.

Workup

  1. customThe title compound was prepared
  2. customPurification by chromatography

Sources & evidence

ORD record
ord-dd0797a9499a4d2a90e7f4fc35606870
Source dataset
uspto-grants-2008_07
Patent number
US07405210B2

Reaction notes

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