Hydrochloric Acid → HCID 86598031, compound

HRID 751758Notes

Reaction equation

HRID 751758 reaction equation
[CH2:1]([O:8][C:9]([C@@H:11]([NH:13][C:14]([C@@H:16]1[CH2:21][CH2:20][CH2:19][CH2:18][N:17]1C(OC(C)(C)C)=O)=[O:15])[CH3:12])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:29]>O1CCOCC1>[Cl-:29].[CH2:1]([O:8][C:9]([C@@H:11]([NH:13][C:14]([C@@H:16]1[CH2:21][CH2:20][CH2:19][CH2:18][NH2+:17]1)=[O:15])[CH3:12])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59753476HCID 59753476, compound

Product 1

HCID 86598031HCID 86598031, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2.30 g (5.89 mmol) of the carbamate from example 20A are dissolved in 4N hydrochloric acid in dioxane (23 ml) and stirred at room temperature for 1 h. The solution is subsequently evaporated, taken up again in toluene and concentrated again. The residue is washed with diethyl ether with stirring and filtered off with suction. 1.70 g (88% of th.) of product are obtained, which is employed in the following reaction without further purification.

Workup

  1. customThe solution is subsequently evaporated
  2. concentrationconcentrated again
  3. washThe residue is washed with diethyl ether
  4. stirringwith stirring
  5. filtrationfiltered off with suction
  6. custom1.70 g (88% of th.) of product are obtained
  7. customwhich is employed in the following reaction without further purification

Sources & evidence

ORD record
ord-5ffaac50c0c544ccb97c0201aba99e11
Source dataset
uspto-grants-2008_07
Patent number
US07405201B2

Reaction notes

Loading…