HCID 59753324, compound → HCID 59753350, compound

HRID 751760Notes

Reaction equation

HRID 751760 reaction equation
C([O:8][C:9]([C@@H:11]([NH:13][C:14]([C@@H:16]1[CH2:21][CH2:20][CH2:19][CH2:18][N:17]1[C:22]([C@@H:24]1[CH2:28][CH2:27][CH2:26][N:25]1[C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])=[O:23])=[O:15])[CH3:12])=[O:10])C1C=CC=CC=1.[H][H]>CO.[Pd]>[C:9]([C@@H:11]([NH:13][C:14]([C@@H:16]1[CH2:21][CH2:20][CH2:19][CH2:18][N:17]1[C:22]([C@@H:24]1[CH2:28][CH2:27][CH2:26][N:25]1[C:29]([O:31][C:32]([CH3:33])([CH3:35])[CH3:34])=[O:30])=[O:23])=[O:15])[CH3:12])([OH:10])=[O:8]

Participants

5

Reactant 2

HCID 59753324HCID 59753324, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 59753350HCID 59753350, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 10.00 g (20.51 mmol) of the ester from example 22A in methanol (100 ml) is treated with Pd/C (1.00 g) (10 pc.) and hydrogenated at RT at a hydrogen pressure of 1 bar. Subsequently, the solution is filtered through silica gel and evaporated. 7.93 g (97% of th.) of the product are obtained, which is reacted without further purification.

Workup

  1. filtrationSubsequently, the solution is filtered through silica gel
  2. customevaporated
  3. custom7.93 g (97% of th.) of the product are obtained
  4. customwhich is reacted without further purification

Sources & evidence

ORD record
ord-e01b1a47e6614c5da0c8d01f793534a6
Source dataset
uspto-grants-2008_07
Patent number
US07405201B2

Reaction notes

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