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HRID751763

反应详情

EQUATION

反应方程式

HRID 751763 的结构方程式

REACTANTS

反应物

3
结构：ClCCl
HCID6344

Dichloromethane

CH2Cl2

结构：O=C(O)C(F)(F)F
HCID6422

未命名化合物

结构：C[C@@H]1C[C@H]2C(=O)OC[C@H](NC(=O)[C@H](Cc3cc(F)cc(F)c3)NC(=O)OC(C)(C)C)C(=O)N3CCC[C@H]3C(=O)N3CCCC[C@H]3C(=O)N[C@@H](C)C(=O)N2C1
HCID59753410

未命名化合物

PRODUCTS

生成物

1
结构：C[C@@H]1C[C@H]2C(=O)OC[C@H](NC(=O)[C@@H]([NH3+])Cc3cc(F)cc(F)c3)C(=O)N3CCC[C@H]3C(=O)N3CCCC[C@H]3C(=O)N[C@@H](C)C(=O)N2C1.O=C([O-])C(F)(F)F
HCID86598033

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

485 mg (0.64 mmol) of the compound from example 28A are introduced into dichloromethane (7 ml) at 0° C. 7 ml of a solution of 9 parts by volume of trifluoroacetic acid and 1 part of water are added and the reaction mixture is stirred for 45 min. The solvent is removed in vacuo and the residue is in each case taken up using dichloromethane and subsequently using toluene and concentrated to dryness. 588 mg of crude product are obtained, which is employed in the subsequent step without further purification.

WORKUP

后处理

  1. customThe solvent is removed in vacuo
  2. concentrationconcentrated to dryness