反应详情

4.22 g (27.3 mmol) of 3-cylcohexyl-2-propenoic acid are suspended in dichloromethane (30 ml), 5 drops of DMF are added and at RT 1.9 ml (164 mmol) of thionyl chloride are slowly added dropwise. The reaction mixture is heated to reflux for 2 h, cooled and concentrated to dryness on a rotary evaporator. The oily residue is taken up twice using toluene, concentrated to dryness and dried in vacuo. 4.72 g of product are obtained, which is directly reacted further.

1. additionare slowly added dropwise
2. temperatureThe reaction mixture is heated
3. temperatureto reflux for 2 h
4. temperaturecooled
5. concentrationconcentrated to dryness on a rotary evaporator
6. concentrationconcentrated to dryness
7. customdried in vacuo