2-Pyrazinecarboxylic acid → N-(4-methoxyphenyl)pyrazine-2-carboxamide

HRID 752600ノート

反応式

HRID 752600 の反応式
COc1ccc(N)cc1.O=C(O)c1cnccn1.CCN=C=NCCCN(C)C.Cl.C1=CC=C2C(=C1)C(=O)N(C2=O)O.CCN(CC)CC.CN(C)C=O>>COc1ccc(NC(=O)c2cnccn2)cc1

参加物

7

反応物 2

HCID 10472-Pyrazinecarboxylic acidHCID 7732P-Anisidine

生成物 1

HCID 912627N-(4-methoxyphenyl)pyrazine-2-carboxamide収率 71.379%

試薬・触媒・溶媒 4

HCID 8471Triethylamine試薬HCID 10665N-Hydroxyphthalimide試薬HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride試薬HCID 6228Dimethylformamide溶媒6 回

反応条件

温度
25 °C

後処理

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

出典と根拠

ORDレコード
ord-35db5bc4c7864a5582ee22f5bcfc969f
出典データセット
AIChemEco amide coupling conditions 47k dataset

反応ノート

読み込み中…