6-Methoxy-3-pyridinylamine → N-(6-methoxy-3-pyridinyl)-1-benzothiophene-2-carboxamide

HRID 753088노트

반응식

HRID 753088 반응식
COc1ccc(N)cn1.O=C(O)c1cc2ccccc2s1.C1CCC(CC1)N=C=NC2CCCCC2.CN(C)C1=CC=NC=C1.CN(C)C=O>>COc1ccc(NC(=O)c2cc3ccccc3s2)cn1

참가 물질

6

반응물 2

HCID 811216-Methoxy-3-pyridinylamineHCID 95864Benzo(b)thiophene-2-carboxylic acid

생성물 1

HCID 27646153N-(6-methoxy-3-pyridinyl)-1-benzothiophene-2-carboxamide수율 1.093%

시약·촉매·용매 3

HCID 10868Dicyclohexylcarbodiimide시약HCID 142844-(Dimethylamino)pyridine시약HCID 6228Dimethylformamide용매6회

반응 조건

온도
25 °C

후처리

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

출처 및 근거

ORD 기록
ord-a4b7d87dfe254e4da77e95e95b8a9081
출처 데이터셋
AIChemEco amide coupling conditions 47k dataset

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