HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Propanol, 1-amino-2-methyl- → Methyl 2-(4-chlorophenyl)-3-(2-hydroxy-2-methylpropylamino)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Propanol, 1-amino-2-methyl- | HCID 95102 | — |
| Reactant | Methyl 2-(4-chlorophenyl)acrylate | HCID 11735736 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Methyl 2-(4-chlorophenyl)-3-(2-hydroxy-2-methylpropylamino)propanoate | HCID 68627364 | 100.4% |
Reaction Steps
1-Amino-2-methyl-propan-2-ol (0.408 g, 4.58 mmol) was added to a solution of methyl 2-(4-chlorophenyl)acrylate (0.300 g, 1.52 mmol) in tetrahydrofuran (3.84 mL). The reaction was allowed to stir at room temperature overnight and produced crude methyl 2-(4-chlorophenyl)-3-(2-hydroxy-2-methylpropylamino)propanoate (436 mg, 100%). LCMS: M+1 286.5.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08835434B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-8540affbea47465aa01b8fb0617ffe81 |
| Source note | uspto-grants-2014_09 |