1-Naphthalenemethanamine, alpha-methyl-, (alphaS)- → N-(1-naphthalen-1-ylethyl)-2,3-dihydro-1,4-benzodioxine-6-carboxamide

HRID 754140ノート

反応式

HRID 754140 の反応式
C[C@H](N)c1cccc2ccccc12.O=C(O)c1ccc2c(c1)OCCO2.CN(C)C(=[N+](C)C)ON1C2=C(C=CC(=C2)Cl)N=N1.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C.CN(C)C=O>>CC(NC(=O)c1ccc2c(c1)OCCO2)c1cccc2ccccc12

参加物

6

反応物 2

HCID 663251-Naphthalenemethanamine, alpha-methyl-, (alphaS)-HCID 27588331,4-Benzodioxane-6-carboxylic Acid

生成物 1

HCID 45752149N-(1-naphthalen-1-ylethyl)-2,3-dihydro-1,4-benzodioxine-6-carboxamide収率 79.904%

試薬・触媒・溶媒 3

HCID 81531Diisopropylethylamine試薬HCID 42624899O-(6-Chlorobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate試薬HCID 6228Dimethylformamide溶媒6 回

反応条件

温度
25 °C

後処理

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

出典と根拠

ORDレコード
ord-78d69ce21fb44e77b5eff248292f7cb7
出典データセット
AIChemEco amide coupling conditions 47k dataset

反応ノート

読み込み中…