反应详情

In a 250 mL round-bottomed flask was placed 6-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-N-isopropyl-2-(4-nitrophenyl)pyrimidin-4-amine (17, 74 mg, 0.200 mmol) in 2-propanol (7 mL) and dichloromethane (7 mL) to give a yellow solution. A catalytic amount of Pd on charcoal (wet) was added and the mixture was stirred under a hydrogen atmosphere for 1 hour. The mixture was filtered over Celite™, rinsed with dichloromethane and concentrated to give the title compound in quantitative yield.

1. customIn a 250 mL round-bottomed flask was placed
2. filtrationThe mixture was filtered over Celite™
3. washrinsed with dichloromethane
4. concentrationconcentrated