Sodium Iodide → 8-(6-Chloro-2-iodopyrimidin-4-yl)-3-oxa-8-azabicyclo[3.2.1]octane

Temperature

0 °C

In a 250 mL round-bottomed flask was placed 8-(2,6-dichloropyrimidin-4-yl)-3-oxa-8-azabicyclo[3.2.1]octane (34, 980 mg, 3.77 mmol) in chloroform (4 ml) to give a very light yellow solution. Sodium iodide (941 mg, 6.28 mmol) was added to give a suspension. The mixture was cooled to 0° C. and an aqueous solution (57% w/w) of hydrogen iodide (4.97 ml, 37.7 mmol) was added, resulting in a yellow precipitate. The mixture was slowly warmed to room temperature and stirred at room temperature for 4 h. The mixture was diluted with water and quenched with NaOH (5M) to pH˜8. Aqueous sodium thiosulfate was added to decolorize. The mixture was extracted with dichloromethane, dried over MgSO4 and concentrated. The crude product was added to a silica gel column and was eluted with ethyl acetate in hexanes (10-40%). Collected fractions were concentrated to give the title compound (516 mg) as a white solid. LCMS analysis revealed that the product contained ˜20% starting material. The mixture was used without further purification in the next step.

1. customIn a 250 mL round-bottomed flask was placed
2. customto give a suspension
3. customresulting in a yellow precipitate
4. temperatureThe mixture was slowly warmed to room temperature
5. customquenched with NaOH (5M) to pH˜8
6. additionAqueous sodium thiosulfate was added
7. extractionThe mixture was extracted with dichloromethane
8. dry with materialdried over MgSO4
9. concentrationconcentrated
10. additionThe crude product was added to a silica gel column
11. washwas eluted with ethyl acetate in hexanes (10-40%)
12. concentrationCollected fractions were concentrated

ORD record

ord-4154d87023ea401f98c68234a7cdf863

Source dataset

uspto-grants-2014_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08835429B2