huagongshe.com
HRID75470

反应详情

EQUATION

反应方程式

HRID 75470 的结构方程式

REACTANTS

反应物

2
结构：CN=C=O
HCID12228

Methyl isocyanate

C2H3NO

结构：CNC(=O)Nc1ccc(-c2nc(CN(C)C)cc(N3C4CCC3COC4)n2)cc1
HCID66750273

未命名化合物

PRODUCTS

生成物

1
结构：CCNC(=O)Nc1ccc(-c2nc(CN(C)C)cc(N3C4CCC3COC4)n2)cc1
HCID66750316

未命名化合物

收率 21%

PROCEDURE

实验过程

A procedure similar to that used for the preparation of 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-((dimethylamino)methyl)pyrimidin-2-yl)phenyl)-3-methylurea was used, substituting ethylisocyanate for methylisocyanate, to provide the mono-TFA salt of 1-(4-(4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-((dimethylamino)methyl)pyrimidin-2-yl)phenyl)-3-ethylurea (0.014 g, 21%) as a white solid. MS: 411.4, M+H.