反应详情

t-butyl 4-(quinolin-8-yl)piperazine-1-carboxylate (compound 32, 2.4 g, 7.66 mmol) was dissolved in methanol (50 ml) and SOCl2 was added to the solution dropwise at 0° C. The resulting solution was refluxed for 1 day and evaporated under reduced pressure. EtOAc (50 ml) was added to the residue and stirred for 2 hours to produce light yellow solid. The title compound was collected by filteration (1.7 g, 89%) as light yellow solid.

1. temperatureThe resulting solution was refluxed for 1 day
2. customevaporated under reduced pressure
3. additionEtOAc (50 ml) was added to the residue
4. customto produce light yellow solid
5. customThe title compound was collected by filteration (1.7 g, 89%) as light yellow solid