Thionyl Chloride → HCID 66888232, compound

Participants

Reaction Steps

t-butyl 4-(quinolin-8-yl)piperazine-1-carboxylate (compound 32, 2.4 g, 7.66 mmol) was dissolved in methanol (50 ml) and SOCl2 was added to the solution dropwise at 0° C. The resulting solution was refluxed for 1 day and evaporated under reduced pressure. EtOAc (50 ml) was added to the residue and stirred for 2 hours to produce light yellow solid. The title compound was collected by filteration (1.7 g, 89%) as light yellow solid.

Provenance & Evidence